I think you could make a reasonable case that at least 7 of the 10 largest US cities were not "major cities pre-car". Depending greatly, of course, on exactly what "major" means. Note that none of these cities resemble older, denser cities like NY in their layout.

LA Houston Phoenix San Antonio San Diego Dallas San Jose

Source: https://en.wikipedia.org/wiki/List_of_United_States_cities_b...