New York City is the most obvious example, but most large east-coast cities were large pre-car. And many cities made major infrastructural changes in light of the car, mostly in the form of the addition of elevated highways, some of which are now being torn out again because of their negative effects on neighborhood continuity, urban fabric, etc. Examples of the former would include the I-395 underpass/mixing bowl into DC and chunk of I-5 that separates downtown Seattle from Capitol Hill, and examples of the latter include the ripping out of the Embarcadero freeway in San Francisco and (likely) the Alaska Way viaduct, also in Seattle.