I listen to No Agenda (JCD & Adam Curry) primarily for entertainment value. My gf and I spend quite a few minutes every week mocking their ignorance. The political stuff is blatantly biased and the faux naive outrage is annoying to the point that I skip most of it, especially the clips. The H1N1 coverage is actually rather an antidote to hysteria - they don't think it's as serious as all that - the hysteria more relates to untested vaccine.

Mostly, though, I just listen for the anecdotes that are actually grounded in personal experience. I don't take either of them seriously in the least. I'd be willing to bet that a significant fraction of their audience is similar (though no doubt there's a larger than average loony fringe too).