LESS or SASS/Compass are you friends :) ...and the only way to maintain sanity when doing heavy edgy CSS3. Once you have your mixins abstracting away browser prefixes and common patterns, you can get to the new level of style patterns reuse with higher-order-functions-like features like LESS's mixins that can take mixins as arguments (great for the @keyframes prefixes madness at first, afterwards only your masochism and imagination set the limit). I'll never be able to stand the pain of writing "plain ol' CSS by hand" again...
Working on a project that relies heavily on CSS3, I have come to the conclusion that most browsers still depend on vendor specific prefixes. Take the CSS animation for instance, without the inclusion of "-webkit-", it fails to work in the latest Chrome and Safari while having no issues on Firefox or IE.
[1] http://www.w3schools.com/cssref/tryit.asp?filename=trycss3_a...