Perhaps, but the use case it usually finds is "I need a webserver, here. Now."

Python is nearly always installed, and that depends on nothing but the standard library. You can stick an alias in your dotfiles (I have, it's called "serve-this") and not have to worry about having twisted¹ getting to wherever your dotfiles get put. (I distribute my dotfiles over git/github, so it's really easy to move them around. More work to get Twisted.)

¹Or Ruby… or Go…