I think that the register and volatile keywords in C and C++ and the inline keyword in C++ basically constitute real world research into exactly that process. In pretty much all cases it seems to have been eventually determined that the combination of the compiler needing to override the programmer's wishes when the programmer was wrong (as well as the fact that it will sometimes implement the optimization without being asked) and the programmer's inability to recognize cases where the optimization will actually make things worse has led to them becoming less and less relevant to the compiler's decisions over time. Usually this results in a "YES I REALLY MEAN IT" compiler directive, which just looks like an arms race.

I suppose it's possible this has been the wrong direction, but I suspect it was effectively correct.

The restrict keyword can be used assist in vectoring your code, which is equivalent to inserting the correct binary instructions and is almost never the wrong strategy

You could quite easily wind up throwing restrict on something that does actually get aliased, which would result in some weird heisenbugs. That said it may be true that restrict will do better than the others have, but it's a lot 'newer' (even though it came from a 15 year old revision of C it seems like adoption of it has been particularly slow) so I'm not sure the jury's out yet.

I'd be interested to see how much of a difference cooperating with the compiler makes. I think the usual advice that until you profile you don't know what the bottlenecks in your code are applies here. Similarly, I think that it is unlikely that the places where humans could add anything of value to the compiler have much of an impact on actual performance (with the exception of types which I'll discuss below).

And in most cases the compiler is much better at optimizing than humans. Register allocation is probably the archetypical example of this. C has a register keyword that the compiler is supposed to interpret to mean "try to put this variable in a register". In most cases you aren't going to be able to perform a liveness analysis of your variables better than the compiler can, and I'm not even sure that modern C compilers even pay attention to the register keyword. They might just perform their own optimizations since compiler writers realize that in >99% of cases, that's going to be better anyways.

Lastly, to touch briefly on types, this is one area that does make a difference on runtime performance. Basically, if the compiler can type check code it can perform more aggressive operations because it can rule out certain classes of errors. Additionally, static types don't have the overhead associated with dynamic typing in terms of tagging variables with their type information. Functional languages in particular are nice from a compiler writer's perspective because if you can guarantee certain parts of the source code are pure you can perform more optimizations that you could otherwise. For example, let's say you're using C++ and you have a function that doesn't return anything, doesn't take any arguments, and doesn't update any globals. A Haskell compiler could probably eliminate this function call, since it doesn't seem to be doing anything, but in C++ it's most likely doing I/O or is being called for some other side effect and so we have to keep it around.

Aliasing information is one place the programmer can help the compiler. The 'restrict' keyword in C/C++ is a great example of this. Also information provided by 'const' can be very helpful for the compiler. While both of these aren't strictly hints because they limit what you can do and still get correct results, they do tell the compiler facts that would be otherwise difficult or impossible to prove.

'const' is a very good example and one I hadn't thought about. To some extent functional languages pass every function argument with const, since the arguments are call by value, rather than call by reference. At first glance this might seem to be disastrous in terms of performance if, for example, you pass in a list with 1,000,00 entries or something like that, but any reasonable implementation of a functional language provides ways of doing this without the excessive space and time costs that a naive implementation would have.

I'm not sure any compiler actually implements any real optimizations based on const. I suppose possibly on static const variables of basic integer types, but that'd be about all it can do. The existence of the volatile escape hatch, to say nothing of const_cast<>, makes it a pretty useless hint for the compiler.

In C(++), the compiler may be able to figure that out. If the function doesn't, directly or indirectly, call any outside function, the entire call tree can be thrown away.

And that can cross libraries: if you #include a standard header, a C++ compiler may assume that calling, say, malloc() or exit() does what the standard says it does. That way, even a function that calls malloc or gettimeofday can be optimized away before it is even linked.

And of course, in many compilers, programmers can use #pragma's or attributes to instruct the compiler "you can assume this function is pure/doesn't return/returns newly allocated memory/etc (http://gcc.gnu.org/onlinedocs/gcc/Function-Attributes.html)

If you do that meticulously, the compiler has way more room for optimizations.

You could argue compilers are good at making transformations to a program for optimization, but they are in many ways information starved. Cooperating with a compiler in the way http://www.yosefk.com/blog/humans-and-compilers-need-each-ot... describes, implies giving the compiler more information, external to the information that can be gathered from the source code. Type information should be helpful (tho disclaimer: I've never written a compiler), but it's information the compiler already has... That's not really cooperating with it. Just handing it stuff.

Regarding the "register" keyword, I'm pretty sure I was reading books in the 90s which described it as a historical curiosity that was ignored by all modern, right-thinking compilers.

(author here) Yes, one of our points is that 'register' is much too low-level, because one can't abstract over it. The same holds e.g. for OpenMP directives. In the paper we propose (among other things) to attach such directives to dynamic scopes. This makes it possible to e.g. unroll all innermost loops, including those in function calls, without putting unrolling directives on individual loops.