I know people that are never wrong. They also don't accomplish much, in fact they are so 'safe' I doubt they'll ever do something in the first place.

If you do a lot chances are that you'll be wrong plenty of times. Given the average score of hits:misses Dean Kamen is comfortably outperforming pretty much any poster on HN, on top of that he seems to be a half decent human being trying to solve problems that really matter. His success rate is only part of the picture. Sure he's got an ego and there seems to be a disconnect with respect to how some 'ordinary' people perceive his products. But I guess that once you reach that level you have to be a very balanced person not to let it get to you in some way.

There is some correlation between having a billion dollars in excess income and being out of touch.