3 out of 4, there's something legitimate there. It's possible to be coached through some of the objective parts of many interview processes, ours included. That's readily true for an internal referral (and could be innocuous rather than malicious), and even someone using glassdoor to prep could maybe skate by a couple questions, but someone will usually sniff it out subjectively.
1 out of 4 it's a "personality clash" which could be code for being threatened by someone's technical superiority, rather than simply being annoyed by someone's superior PITA-ness
If the same employee is constantly on the personality clash side of things, it's easy enough to remove them from future loops (and possibly the company, if their inferiority complex is rooted in actual inferiority).
does this ever actually happen? it would never fly during any of the interview processes I've helped conduct.