Re:Immunity Project – HIV Vaccine Development Program [pdf]
by rgejman on Tuesday January 28, 2014 @12:44AM
(#7135564)
I think that they will incubate CD8 and CD4 T cells from the same mouse together. The CD8 (cytotoxic) T cells, if they recognize the antigen, should kill the infected CD4 cells.
A caveat is activation/co-stimulation. The CD8 T cells should already be activated due to the vaccination and no longer need co-stimulation from DCs... but this depends on the vaccine having delivered enough peptide to stimulate a true immune response in a human/humanized immune system. That's the (first) big unknown here.
A caveat is activation/co-stimulation. The CD8 T cells should already be activated due to the vaccination and no longer need co-stimulation from DCs... but this depends on the vaccine having delivered enough peptide to stimulate a true immune response in a human/humanized immune system. That's the (first) big unknown here.