When you speak of extreme specialization I can't help but think of The Machine Stops by E.M. Forster.
http://www.plexus.org/forster/index.html
Sometimes I worry that there aren't enough inter-disciplinary and trans-disciplinary thinkers. Of course, it may just be because I'm around a lot of academics who seem to be highly specialized.
That said, with extreme specialization being the norm these days, I think there is a dearth of inter-disciplinary and trans-disciplinary thinkers, to unify the vast amounts of knowldege divided within and between fields, and to bring perspective to the almost unimaginable technology mankind will be able to wield in the next 20-40 years.