I achieve this by having multiple users in Chrome. My main user is signed into my google account and has no extensions installed and all plugins disabled, I only access gmail and google services with it.

My second user account is logged into basic services like HN, reddit, amazon and has only adblock and disconnect installed.

A third user is not logged in anywhere and has adblock and a half-dozen other extensions installed including UA switcher. No plugins installed and cookies + cache cleared every day.

4th user has all the anonimity extensions installed and has privoxy + tor set as the proxy

I use Facebook in a completely different browser again, YouTube and video watching in yet another and development in chromium.

7 or 8 different cookie stores, and a throwaway temp email account associated with the 3rd and 4th user for signing up to services.

Start out by creating a separate user for browsing sites and eventually develop your own way to split up your web browsing profiles.

This can get a bit messy when you try and access from tablet or mobikle , but I'd rather not have a single large profile and a huge exploit surface and sacrifice browsing history and remembering passwords.