We're currently using Django Compressor [0], and it works pretty well. It was slightly annoying to get it to work well with staticfiles [1], as we host all of our content on S3 and serve through cloudfront in production. But, it's nice because now we can do this in our template:

    <script src="{% static js/mylib.js %}"></script>

and with compress like this:

    {% compress js %}
      <script src="{% static js/mylib.js %}"></script>
    {% endcompress %}

so that referencing static files is consistent.

[0]: https://github.com/jezdez/django_compressor

[1]: https://docs.djangoproject.com/en/dev/ref/contrib/staticfile...