It would be a really interesting experiment even: divide up a big problem into 100 or so features and assign each feature to a random person. Give the students some time to work out who they need their code to communicate with and draw up some simple interfaces. Use github or similar with an account for every student. Make the TAs in charge of accepting pull requests. It could be the main focus of a software engineering course.
EDIT: The students wouldn't necessarily need to work with all 100 others - only the ones whose feature their feature interacts with. eg, 1 student could need to receive input from 5 inputs and calculate some statistics - he would only need to talk to the 5 students who would feed him data, and then talk to the 1 student he would feed data to.
Of course then you'd have the student that forgot to include SQL injection protections getting their project goat.se'd during a demonstration.
I up-voted your comment as a whole, but I really disagree with this statement. It's reality in many situations, but I think it's a shame that anyone has to work together with a team of 100 on anything, ever. You deal with it, and you solve the problems associated with it, but those are problems of management and process.