Interesting quote I heard last week, from Stephen Fleming, successful VC and now Vice Provost of Georgia Tech. It was something like, "I've never seen a married founder bootstrap a company to a large exit and had the marriage survive."
I think it depends upon what value of large. One counter-example: Greg Gianforte bootstrapped RightNow technologies to 100M in revenue, still runs the company, and is still married. Two others would be Bill Hewlett and David Packard.
I have a lot of sympathy for old-school businesses that need a lot of operating capital. Putting your house in danger to support your business is a choice I hope I never have to make. In my case, that would essentially be the same as putting my marriage on the line.