Which is basically how serious psychonauts perform this experiment for themselves. The microdose threshold seems to be somewhere between 8ug and 30ug, depending on the person.

SWIM have tried 20ug and reported increase of energy comparable to drinking several energy drinks and have crashed pretty hard after 5 hours with increased perspiration, chills and unusual tiredness. He talked about mood elevation, heightened perception and both ability to faster enter "the zone", but also inability to stay there for a longer periods. He wanted "to have some fun" and "be more active" instead of programming.

He did not recommend it, because simply getting a better sleep and a nice breakfast have been more productive for him.