It really depends on the structure of the business and market you're trying to crack. Also, remember VC is the most expensive and controlling capital you will ever raise, and you should try to avoid it unless there is a compelling reason to use it (like network effects, fast growth and no profits for 10 years). Instead, the best money you can raise is from customers, which has the added benefit of not needing to be repaid, and providing perfect kinds of feedback data for your product. This was advice from Nolan Bushnell, and worth considering.