I switched to Dvorak seven or eight years ago to see if it would help with RSI issues I was having. It helped a lot, and I never switched back. Sometimes I have to type QWERTY (at kiosks at the library, for example) and I just laugh at how ridiculous my hand motions become when using it. For people experiencing wrist pain while typing, I recommend trying it. A lot of people use it (compared to other minority layouts), so support is widespread.