I'm in Silicon Valley, but really dislike Silicon Valley, and looking at how to be in Seattle (or maybe Austin, or non-USA). (Silicon Valley still makes sense for the earliest stages, but I don't think I'd recommend people move here if they already have a going business, unlike 5 years ago.)

I think in the past couple years, things like funding have become more global, and there's a strong case for having a small presence in SFBA and a larger presence in a place like Seattle, Austin, Boulder, or really anywhere with a concentration of talent for hiring. I'm hoping to check out some Asia/Pacific places in October/November, and Central/Eastern Europe around xmas.