It is inevitable that as companies get bigger, the things they do to allow them to scale takes away from their nimbleness. I can't think of a single instance of where the largest company in an industry is the most nimble.

Coordinating people takes effort and standardization. Also, the larger you get, the harder it is to outgrow your market. This is the price you pay for winning. It's also why employees leave as companies grow. They say, "It just doesn't feel the same" because what got the firm from 100 to 1000 employees isn't what scales them to 10000.