Promises help with this quite a lot. http://promises-aplus.github.io/promises-spec/ What 3.2.6.2 means is that any thrown exception is caught and turned into a rejected promise which will bubble up (across async boundaries) until it gets to a rejection handler.

I haven't had too much experience with Domains, but I believe they are generally used for courser grain error handling (because it's a bit verbose to attach them all over the place). E.g., to catch most errors (it's no guarantee what 3p libs do to your context) generated in fulfillment of a particular web request.