//FOLLOWING IS NOT RELATED TO THE ACTUAL TOPIC, COMPLETELY SEPARATE AND SPECULATIVE
As for the particular case of sex hormones you're right that we don't have a solid solution yet. But having said that many papers show that anti-androgens might not destroy male fertility even with long term usage. Actually that research kind of helped introduce the chemical-castration penalty in many countries, cause it's supposed to be reversible in terms of fertility (not to say it's every single effect is reversible. The evidence is pretty strong, but could be better. Other solution is simply castrating yourself after you have the number of children that you want to so that you don't care about fertility. For women I think it would be taking uterus and ovaries out. The thing is with women the life-expectancy might or might not be significant. But not having period would probably be nice.
Personally I don't know. My gut feel on these issues tends to fluctuate. It's actually kind of amazing - when you go and read actual papers and look for proof of this or that it often turns out nobody really knows. The line between something being good or bad (for health) is so very thin sometimes. Gosh, I wish I could get an answer on the whole supplement thing.
Cause if so, I don't know what you're smoking. I can tell you from personal experience that modern medicine does not have sex hormones completely figured out, nor do we have a way to replace them entirely with something 'better'...