https://news.ycombinator.com/item?id=1635236

If you have a spouse of any description, it's definitely worth looking in to a separate office. Nearly all the issues I've run into over the years of working remotely have stemmed from being physically present in the house/apartment during daylight hours and thus physically capable of answering "quick questions", having things "just put away" in my office, or "letting the electrician in" (and spending 45 minutes explaining to him the various things we needed him let in to do.)

If you're in a separate office across town, or even a shed at the end of the garden, that sort of thing stops happening and you get back to potentially being able to work a full day uninterupted.