The first thing I do when setting up Firefox is configure some keyword searches. Second, I remove the search box from the toolbar. I guess I miss search suggestions, but I'm more of a quickly-type-a-query-and-then-hit-enter person so I don't gain much from suggestions when I use Chrome.

What I miss, however, is a way to configure search engines and keyboard search without re-enabling the search box. I wish it was somewhere in settings or an about: page.