I wouldn't call missing those things "the end of the world" unless you are really dead set on that route.
Getting poor (or even average) grades closes many doors, especially in these days of grade inflation (at many, but not all schools).
Matter of fact those are 3 skills that are always in demand because anyone who possesses them can avoid truly coming to grips with the question in this thread: The necessity of good grades in determining your career.
Bulk of medicine is how much you can remember. There is nothing like, let me work this out on a paper or fire up a REPL, in fact in their case- Something like putting a patient on pause while you refer a book is totally unacceptable. So remembering stuff all around.
I realized this pretty early and decided not to be a doctor. I just can't imagine my self memorizing things at such detail.
The person did so well on Step 2 that s/he was invited to transfer back to the US at a fist tier medical school, and is now the director of cardiology at a prestigious hospital.
If you're trying to get into medical school, that's not really a fair question. Your college GPA directly affects your med school prospects, which greatly affects your residency prospects, and in turn your lifetime career earnings. If you're getting B's in level 1 & 2 physics and chemistry, you're not getting into Harvard.