I've forgotten to bring my wallet/keys with me when I leave my place, I've forgotten to wear my glasses before driving somewhere, I've forgotten to turn on my headlights while driving (in a well lit city, to my credit). People accidentally carry pocket knives through metal detectors.
None of these thing are something that happens to most people often, it could happen just once after years of correct routine. Theses absent-minded mishaps are just human nature. They are of course going to occasionally happen with guns too. I'm sure there are more than a few cops out there who accidentally walked through metal detectors while wearing their service pistol.
My point is, guns are a bit more dangerous than knives, and the responsibility of the holder should reflect that.