And that was the research which led to the rejection of LSD as a model for schizophrenia, and there is still no evidence tying LSD to schizophrenia as all the correlations are heavily contaminated by polydrug use.
It's messy, but https://en.wikipedia.org/wiki/LSD_and_schizophrenia is a better overview of the topic...
Most of the lsd-eaters I've talked with have talked about a visual effect called "tracers", but the handful of schizophrenics I've talked to don't talk about tracers, but they do talk about hallucinatory voices, depression, paranoia and confusion.
That said, I think that your current brain chemistry definitely affects your drug experience. If you have mental health issues, stay away from hallucinogens.
Like I said in another post, I have used psilocybin. The effects I had were not typical of what most other people described. I had a whole other set of "special effects" I experienced, consistently. After talking with many people, I found that a few other people shared virtually the same hallucinatory effects, and they seemed to have ADHD or some kind of OCD or were very tech-geeky. (And, I haven't been diagnosed, but I bite my nails and have a mild hoarding problem. That's a sign of possible OCD.)
So, I don't seek out this type of drug anymore.
Drunken people share symptoms with schizophrenics too, as well as people who have gone without sleep.
Haloperidol and olanzapine, two common prescriptions for schizophrenia, have been demonstrated to reduce the effects of LSD.
There is a connection between the psychoactive properties of LSD and the neurological etiology of schizophrenia, though the connection needs to be studied further.
Yes, research should not be taken as gospel, but it is foolish to think that there is no reason at all for alarm.
Another more recent source: Marona-Lewicka, D., Nichols, C. D., & Nichols, D. E. (2011). An animal model of schizophrenia based on chronic {LSD} administration: Old idea, new results. Neuropharmacology, 61(3), 503 – 512. doi:10.1016/j.neuropharm.2011.02.006
So the drug is useful for inducing the symptoms, however once the drug is gone so are the symptoms. Schizophrenics have problems at some cellular level, be it receptor, transcription, translation, protein modification, etc that leads to their symptoms and the end effects that are similar to LSD. LSD causes the final step in the pathway, not the initial ones.
Likewise for your drugs, you named two dopamine blockers (one selective for D_2 and one not). these treat schizophrenia in the sense that they minimise symptoms since they are working at the final step in what is wrong with the patients. They are not "cures" because they don't address the initial issue, which we hopefully will discover.
That is such a bullshit statement. A wide array of pharmaceuticals reduce the effects of LSD as well as other drugs for that matter.
Dont mean to be rude, but I'm calling out your schizophrenia association as wild-eyed bullshit, too.
This is very misleading at best. LSD use causes direct symptoms of psychosis, including symptoms of schizophrenia, schizoaffective, and schizophreniform disorders.
The effects of LSD resemble schizophrenia so closely, in fact, that it has led to studies on rats using LSD as a hypothetical model to represent schizophrenia. In other words, we give rats LSD and see what chemicals reduce the effects to find treatments for schizophrenia.
A very incomplete list of sources:
Aghajanian, G. K., & Marek, G. J. (2000). Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Research Reviews, 31(2), 302-312.
Crow, T. J. (1980). Molecular pathology of schizophrenia: more than one disease process?. British medical journal, 280(6207), 66.
Schneier, F. R., & Siris, S. G. (1987). A review of psychoactive substance use and abuse in schizophrenia: patterns of drug choice. The Journal of nervous and mental disease, 175(11), 641-652.