That's one weakness of Objectivism which has become more apparent to me in the last few years. The philosophy seems to almost construct a platonic form of "rationality" and "self-interest" and never really reconnect with concretes, staying entirely in the abstract. So it ends up handling most cases pretty well, but a lot special cases get left behind.

Still, when I re-think through her reasoning again and again, I don't see how one could reach any different fundamental principles. Special cases are just that, and the best course seems to be to just deal with them as they arise.