No. Effective drugs don't need big marketing budgets. Why? Because they are effective. And health care is market is with fixed demand. If your drug is best in class everyone with this condition will take it. They will go with second third line of defense drugs only if the primary is not suitable in the case (side effects/other conditions).

And if you want to boost the sales of your second line drug convincing people it is the best you are actively hurting the patients.