Skepticism is all fine and good, but I don't need to run extensive tests, theorize and test to see if the huge, brown, roaring animal in the woods is a bear. Sometimes, 90% probability is a good enough approximation to go with. Sure, you fool yourself 10% of the time, but you save a lot of time the other 90%.

Based on this, I think we can preliminarily say that putting the "E" on the home row is probably a good idea.