At first it struck me as absurd: "you can't build a computer for functions that don't exist." Um, right. But that's exactly it. Tomorrow there will exist functions that don't exist today.
Or, from the classification/sensor perspective: "choose any number, I can then add 1 to it and my number will be larger than yours." Um, yeah. But again the UTM is part of the universe and therefore can't contain more information than the universe. Tomorrow the quantity of information in the universe will have increased and your formerly universal TM will fail.
The speed issue is kind of a red herring. If you created the ultimate cisc computer that could compute the entire universe in a single clock cycle it would be constrained by size rather than speed. And tomorrow it would fail.
Definition of function is basic set theory / category theory: http://planetmath.org/encyclopedia/Image2.html
EDIT: let's say the function computes the average age of all living people. So at time t=1 the domain is people alive at time 1 and at time t=2 the domain is people alive at time 2. He's saying that the input to the function is a variable called "people" which keeps changing, but that's not how it works. The input to a function is always a fixed value. The functions defined at times 1 and 2 are different functions because they're defined on different domains.