I think that both good/x10 business people and hackers need similar personality traits (or let's call them habits) - focus, persistence, and willingness to learn. Concrete skills like talking to or with people you have never seen before, or learning a framework in the matter of days, can likely be acquired when trying long and hard enough. E.g. I learned to learn new songs in the matter of half an hour or less; I'd never imagined I was capable of that! But it's a skill just like any other.
But we really have to _want_ to get good at something in order to do it. Staying with the guitar example - I can do finger exercises for months and months, but if I don't have a lick I want to eventually be able to play, I will not follow through, whatever focus and persistence I put in during exercise. That's why I prefer to sketch out interfaces before implementing them - hacking and Photoshopping is just a necessity in order to get the product I dreamt up. I do enjoy programming, and I do it focussed and persistent, but I have to really want the outcome (in that case a cool interface and UX).
The one consistent element of natural talent that comes up in intellectual/creative pursuits is working memory. The average person can hold roughly 7 "units" of information in their brain[0], which is why phone numbers are 7 digits long. When sightreading, pianists with a high working memory effectively have an advantage of a few extra years of practice[1]. I would imagine that a high working memory is also helpful in programming, as it determines how large a program you can easily hold in your head.
[0]: it's a little more complex than just 7 pieces of information, see http://en.wikipedia.org/wiki/Working_memory#Capacity
I tried for 2 years to get good at guitar. Never got good. But didn't practice very often either.
Then one I sat down at a drum set and was immediately better than the drummer in my band. I had a knack. It was so fun to play those beats that I practiced almost every day for many years, and still do. And have gotten pretty darn good.
Natural ability turns into learned skills.