For tmux, I assign the bind-key to backtick (`) and last-window to TAB. Then do most of my work in window #1. On a US keyboard, I find it pretty easy to move between windows with `1, `2, `TAB, etc.

Remap caps lock to be a ctrl key, then preferably remap your prefix key to a. Caps+a is way easier to type.

Ctrl+L is good because it's on the home row and typically used for uninteresting stuff anyway (like refreshing the terminal window).

My sequence to actually refresh the window is "Ctrl+L L"

I would find Caps+a very difficult to type (since it uses the two weakest fingers). Have you ever tried Caps+d or Caps+f?

I do ctrl+o because I hated having to hit ctr+a two times to go to the beginning of the line in console apps.

This is also what I do.

Use the Alt key to navigate around: https://github.com/nviennot/tmux-config

It may just take a bit of work to make sure that the important tmux keybindings don't clash with those of the applications you will be running.

Remap your keys. Capslock makes for a very nice control key, cause really, that's the single most used modifier/power key that gets used aside from maybe shift. You can also remap the "lead-in" character.

I use ^j on both screen and tmux (tmux isn't on our prod servers). This frees up ^a in screen so ^a can send me to the beginning of a line, which is quite nice as I write a lot of long commands and it works in several different programs. It's just a really easy combo to hit that avoids chording or stretching your hands to do something like that constantly. My right hand does not hit the 'b' key for squat.

Honestly, a lot of stuff is configurable so that with some thought and planning (and knowledge and research) you can relieve a lot of weird movements with your hands.

I somewhat agree, and the suggestions from others are good, but something that also is a big help with RSI: take more breaks. I have a script set up to remind me to take a break every hour, and it dims my monitor for 10 minutes each time. That has made the largest difference for me.

RSI?

Residential Services, Inc?