Pepper for one is a pretty good reason IMHO
Anyway, he said that the problem with Pepper is that its API is gigantic and its only spec is the implementation in Chromium. Other browsers could port the API but it come at very high cost due to WebKit-specific glue code.
That isn't quite true anymore either, because of Web Workers and ParallelArray.
https://bugzilla.mozilla.org/showdependencytree.cgi?id=80186...
Quote from yesterday's discussion:
https://news.ycombinator.com/item?id=5451658
"WebWorkers are not really a multithread model. Game engines could be written to leverage message passing based isolates, but in some cases, but doing it in an optimal form isn't exactly developer friendly, it's one of pains of developing the PS3 SPEs is that they didn't share system memory and you had to DMA stuff around."
For an alternate model of parallel computing, WebCL (OpenCL) has been ported to Node.js as well: https://github.com/fifield/node-webcl
I'd love to be proven wrong.