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Re:A farewell to bioinformatics (2012) by alephnil on Sunday January 27, 2013 @11:19AM (#5124651)
It is far more difficult than sequence alignment. Sequence alignment has quadratic complexity, while fragment assembly is NP-hard. Se for example

http://scholar.google.com/scholar?cluster=131745416915434219...

Re:A farewell to bioinformatics (2012) by dalke on Sunday January 27, 2013 @06:15PM (#5126111)
Yes, for pairwise sequence alignment. The globally optimized multiple sequence alignment problem is NP-complete.