Saved my &*s on several occasions allowing me to connct to a 'non-Internet' facing server.
Does not really have an enterprise feel to it and wonder if it ever will. It also lacks an open protocol description and/or clients on iOS or Android. However, an older build for ARM/Maemo is available. The lack of this limits it currently to a Windows and Linux environment.
Also, I wasn't involved with Hamachi for few years now, but I think they had a plan to switch to TLS altogether, so that must've been done by now.
I wonder if Salesforce, Oracle, Microsoft Azure, etc. would be likely to do some kind of virtual/software defined network thing in the future. It's an obvious choice for an IaaS provider, but being able to put your SaaS or PaaS on a customer-defined network makes a lot of sense too. Would love to talk to those guys.
It was indeed widely used in gaming circles, but gamers weren't really the target market I designed it for. They just happened to come along in droves, because I added support for network broadcasts and that made LAN games playable over the internet.
Though I wrote the damn thing, so I'm probably biased.