I think you only start getting seriously bad impacts in non-Romance languages where they have their own alphabet, or use the English alphabet phonetically causing letters to appear next to each other that never would in English. E.g. in English "qu" is a pretty obvious token, you rarely see a Q without a U after it. Happens all the time in anglicized Middle Eastern words, though. Quran is like a whole other thing, you'd almost always expect another vowel after qu, not a consonant.