On the one hand, literally every development in this field will reduce uncertainty somewhat.

On the other, we're still very much in the time of headlines which should say "in mice" but don't because the uncertainty is that level of bad.

Uncertainty will have to come down a long way before we can even do without animal testing, let alone do without human testing.

Currently? Of course they don't.

If a level of intelligence far beyond humans is achieved, it probably could eliminate most of the uncertainty about new treatments.