I dunno, I have tried it, and it was ok after a bit on the touchpad. Then I plugged in a mouse. Did not work at all. I could not use it like that. So now I have scroll reverser[1] to scroll that way with just the trackpad. But really, I was flipping back and forth with the settings (there was something weird with the back/forward swipes for browsers) I don't even know which way it is right now. But it doesn't matter, as soon as I start moving it I can get feedback and do it correctly. So I can get used to having it flipped on me rather quickly. I might make some false starts.

[1]: http://pilotmoon.com/scrollreverser/