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A comment on Castration extends life span, but in a surprising way, mouse study suggests.

Re:Castration extends life span, but in a surprising way, mo... by r0meo1 on Monday November 09, 2026 @12:51PM (#50428911)
my guess is IGF-1 is probably one of the biggest reasons, male castration will lower IGF-1 permanently, there's already been other studies showing both animals and humans with lower IGF-1 levels tend to live longer than those with higher levels
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Re:Castration extends life span, but in a surprising way, mo... by cj on Monday November 09, 2026 @12:56PM (#50428991)
IGF-1 can promote cancer growth. (I don't think it causes cancer, but improves the environment for it to grow)

Testosterone plays a role in stimulating release of IGF-1.

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