News for hackers. Stuff that matters.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by kanzure on Sunday November 08, 2026 @02:42PM (#50416411)
pton_xd posted and then deleted:

> There is the whole problem of biology, but LLMs do have one advantage over humans: they just do what they are told and aren't subject to optics, politics, profit motive, etc. Maybe that strengh alone will allow them to surface solutions that would've been buried somewhere along the way otherwise.

Oh, absolutely. There are lots of solutions and low hanging fruit in biology for problems like, say, longevity. We have made mice live significantly longer, several dozen times. But it requires human germline genetic engineering to port to humans, and you can bet that "solution" is pretty heavily tabooed.

As for "curing cancer", I suspect that Anthropic or OpenAI will use their high status/reputation to launder the existing solutions (germline, p53, enhanced DNA damage repair pathways, higher tumor-suppressor-to-oncogene copy number, more robust tumor-suppressor networks, more self-anti-cancer apoptosis, CD47 suppression, etc) that society has refused to accept. They might have enough reputation to get people to look at these ideas. It won't cure people with stage 5 turbo-cancer a.k.a the walking dead, but hopefully we won't be moving the goal posts _that_ much on them. https://news.ycombinator.com/item?id=49329717

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by nullc on Sunday November 08, 2026 @02:54PM (#50416515)
On cancer, look at the history of the discovery of BRCA. The data said that vulnerability was extremely heritable. Mary-Claire King's view is that the development of the genetic contribution to cancer was heavily driven by the politics of eugenics-smell.

It's incorrect to say that AI isn't subject to politics, however. That's a choice we can make or not make. I suspect that if Claude existed in the 1980s it would discard the cancer/genetics link as being pro-eugenic racist ideology which has been rejected by the scientific community-- just as many scientists did back then.

I think this is a big reason why we must reject the centralization of AI. Discovery of that one genetic marker has saved countless lives, but it's not something that the scientific community as a whole was going to do then because of eugenics over-correction and similar political factors. Discovery is easily stimmed for the lack of sufficient hetrodox thinking.

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by watwut on Sunday November 08, 2026 @03:26PM (#50416789)
> LLMs do have one advantage over humans: they just do what they are told and aren't subject to optics, politics, profit motive, etc.

But none of that is true? They dont just do what they are told, they go to tangents and ignore instructions. They are subject to optics, politics and profit motive - see Mecha Hitler for simple obvious example.

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by solenoid0937 on Sunday November 08, 2026 @04:25PM (#50417458)
I swear half of HN has not used a frontier model since 2024.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by tehjoker on Sunday November 08, 2026 @04:30PM (#50417508)
I swear 95% of HN has no idea what politics are much like fish do not think much about water.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by stratos123 on Sunday November 08, 2026 @05:13PM (#50417950)
What do you mean? It's true of frontier models in 2026 that they have a huge cheating problem at hard problems (in fact, it may have gotten worse since 2024, due to all the RLVR), and also that they have baked-in political biases.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by RandomLensman on Sunday November 08, 2026 @04:14PM (#50417318)
What is low hanging fruit that we know how to actually do with germline engineering for humans and not as some highly speculative thing that requires overcoming a lot of issues? And how much lifespan would it add?
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by kanzure on Sunday November 08, 2026 @05:17PM (#50417980)
Of course there are lots of issues. That's the nature of work. But you do it anyway and figure it out.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by mik1998 on Sunday November 08, 2026 @04:19PM (#50417394)
[delayed]
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by tehjoker on Sunday November 08, 2026 @04:28PM (#50417490)
> It won't cure people with stage 5 turbo-cancer a.k.a the walking dead,

Definitely spoken like someone who knows real cancer patients and cares about cures and not like someone religiously obsessed with transhumanism.

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by kanzure on Sunday November 08, 2026 @05:19PM (#50418011)
Huh? I never said my own goal was curing cancer. There are many other people working on cancer. However, I actually do think we can get lower cancer rates via germline genetic engineering, based on the available evidence so far, but again cancer isn't my focus.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by ponector on Sunday November 08, 2026 @05:29PM (#50418106)
>> LLMs do have one advantage over humans: they just do what they are told and aren't subject to optics, politics, profit motive

This can say person who barely used LLM and not understand what is it.

It will ignore instructions, has bias and is censored. Also a provider has profit motive to give you more verbose answer to bill you more tokens.

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by analognoise on Sunday November 08, 2026 @06:48PM (#50419017)
> that society has refused to accept. Source? This kinda sounds like crankery to me.
Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by kanzure on Sunday November 08, 2026 @10:07PM (#50420533)
If you mean that you are unaware of society's prevailing attitudes, then consider https://en.wikipedia.org/wiki/He_Jiankui https://diyhpl.us/wiki/transcripts/makepeoplebetter/episode-... ctrl+f "hospital" and see his ethics manuscript that was censored.

If you mean that you are unaware of substantial progress in germline genetic engineering, then there are many animal model research studies to consider. You can trivially search for them like "germline mouse longevity". Would they translate directly? Like other mouse science, probably not. Would it require work and effort to continue these directions? Yes.

Re:Silicon Valley Promises AI Will Cure Disease. Drugmaker C... by danaris on Monday November 09, 2026 @02:24AM (#50422199)
Worth noting, too, that even without LLMs contributing significantly, we've been making huge strides in curing many cancers, mostly with mRNA vaccines and similar medical technology.