The Windows settings scale resources for the OS, not per application. The more applications you use, the worse these settings become. If I'm unable to use an application's own features to modify the size of something in its UI, I have to fall back to the Windows settings. That leads to the following:

1. Use the make everything bigger/font size settings to increase the size of what I currently can't see

2. Restart

3. Open every application I need, and go through every major feature in each of them to determine if I can still see things comfortably, while making sure no elements have exploded in size as this also leads to usability problems

4. If not, go to 1

I have to do this every time I install a new application, or one of them updates and changes their UI or decides to opt into the Windows accessibility settings. The latter one happened a few years ago with Firefox, and cost me a day to sort.