The question can actually be generalized further - is it the case that for any solvable problem it's possible to find a solution without verifying every possible solution, and more specifically, only a tiny subset of the solution space? This would apply even beyond P vs NP, the same question would arise for EXP vs NEXP (that is, problems where we can find a solution vs just verify a given solution in exponential time), and same for factorial or Ackerman or any other complexity we want to imagine.
Looking at the problem in this way should also make it easier to construct a more strictly practical version of P vs NP, though it actually gets much harder to pin down details. That is, we can construct complexity classes that better match "what is plausibly solvable with a real computer" vs "what is plausibly verifiable with a real computer" and ask a similar question: given any problem of the second kind, can there be any generic algorithm of the first kind that would solve it?
I might be misunderstanding you, but this surely depends on the size of the candidate set in the problem. For a problem like "determine whether a given list of integers of length `n` contains a pair that sum to 100" the naive brute-force algorithm is polynomial. If you replace "pair" by "subset" then the naive brute-force algorithm becomes exponential.