Every time I use a giant-screened Android device I have this feeling. Even now that I'm used to the operation of one, I still feel like I can move so much faster with one hand on an iPhone. Like I can't help myself from bringing up my other hand for something I would do with one hand on an iPhone. Bulky cases also tend to exacerbate the situation.

Kinda like the App Switcher, it's something iOS & the iPhone get a ton of shit for, but in practice I'm so much slower at one-handed navigation without it. That could also be because I'm a lefty, though.