There is a difference between "animosity from others" and outright hatred, violence and oppression. There is a difference between "animoisity" and being denied many of your rights and being locked up in a mental institution ( 11 yr old trans girl institutionalised: http://www.pinknews.co.uk/2012/01/31/german-trans-girl-to-be... ).
Banning people they disagree with from a rather public forum like a subreddit, for example, only hurts their cause and their reputation.
I disagree. I think there is empirical evidence that the LGBT or Trans rights groups have benefited from having safe spaces. Trans rights and LGB rights & politics have increased over the last two decades, in part I think due to more trans & LGB people coming out because they have safe spaces to explore themselves.
Blatant hypocrisy will never help improve the situation, however. One group of people who complain about being ostracized when they're in the minority should not turn around and ostracize others when they're in the majority.
Banning people they disagree with from a rather public forum like a subreddit, for example, only hurts their cause and their reputation. It creates more animosity. Denying the basic ability of one to express himself or herself is just not justifiable.