I'm no expert (yet?) but my understanding is that unless you are in a web-app (in the OS sense, ie: not in a browser strictly speaking) you loose access to features like real sockets and such. WebRTC looks awesome but the fact that we still can't built a true P2P system in HTML5 is a big failure from my point of view... Still, I think this is the way to go for now, not strictly of course... :)