This was before AI got good, so I would do it differently today.

Back then, I got my genome sequenced via nebula genomics (no longer around). I found a lab that screens ~150 genes that potentially contribute to circadian disturbances. I punched all of those genes into this software called gene.iobio that came with the nebula report, which reports any potentially interesting variants and links out to Clinvar. There were a ton of results, everyone carries loads of these harmless variants, but the one that jumped out was in a gene I knew played a critical role in clock timing, and amazingly, that was it.

Any high level on what you'd do today? I'd love to get mine sequenced at a place that won't sell it to a health insurance place. I saw @pcollison post about unleashing coding agents on his being fascinating, I'd love to know more.

Be sure to use local coding agents! Not much use spending more to do more private sequencing then exposing the data to the internet some other way.

I’ve personally not (yet) sequenced my genome. That’s where my personal decision is at, and will remain till data ownership for genomic data isn’t guaranteed. That one big part of me I don’t want to surrender to the all consuming digital aether until I absolutely need a test.

When that time comes, I’d try get a whole genome assay. It’s pricier, but the data is gonna be there as more and more evidence about various polymorphisms come to light. Equally, such data is potent in the wrong hands. D