Mind-altering drugs played key role in rise of Andean civilization

Re:Mind-altering drugs played key role in rise of Andean civ... by TimTheTinker on Monday September 14, 2026 @11:30AM (#49698646)

It's clear that nicotine binds to those receptors, but exactly how that plays out is far more complex in practice, depending on a whole host of variables.

- Presence or absence of other nicotinic agonists, inverse agonists, and antagonists, and relative concentrations of each

- Effects vary wildly with nicotine concentration levels in plasma/interstitial fluid, as if it's an entirely different drug depending on how much is present

- etc.

You're drawing a direct line from one agonist the paper only mentions once to a psychological effect that the paper doesn't even describe. You may or may not be right, but this paper is at best a citation for a separate study to test your hypothesis.

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Re:Mind-altering drugs played key role in rise of Andean civ... by freebsd_lovefes on Monday September 14, 2026 @03:41PM (#49702766)

Please state your conflicts of interest before you diminish the impact of that research some more. Can you make yourself argue for the positive effect that article has even a tiny bit? That we are a happy peoples who are discovering just how profound of an effect nACHR agonists like nicotine can have? Focus on the positives.

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Re:Mind-altering drugs played key role in rise of Andean civ... by TimTheTinker on Monday September 14, 2026 @05:28PM (#49704355)

No conflicts of interest, and I'm not diminishing the impact of the research, just questioning how much it supports your statement.

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