Yes, definitely: the GBA is a 32-bit ARM with 256 KB of RAM and mature GCC support, so it sidesteps everything that made this hard: the 16-bit size_t, the far pointers, the barely-stress-tested compiler. The SNES was the fun target though ;)

How do you deal with things like e.g. writing sprite bitmap data to specific locations in the VRAM from Python? Or handling the memory-mapped I/O?

(By the way, several of your posts seem to be getting automatically filtered. I vouched for this one; I see nothing wrong. Perhaps someone else thought it was AI-generated.)

Does MicroPython support some concept of an "extension module", at least? It would be nice to be able to load new sprites etc. from Python at runtime.