GLP-1 drugs led to weight loss and reversed depression-like behavior in mice

Re:GLP-1 drugs led to weight loss and reversed depression-li... by QuiEgo on Sunday June 28, 2026 @12:24AM (#48704330)

That sucks. If GLP-1s work for you, more power to you.

Curious: how big of a calorie deficit did you run, and what was your macro (protein/fat/carbs) balance.

My personal experience is going low on carbs (especially added sugars) and high on fiber and protein made running a deficit suck much less in terms of feeling satisfied.

Also, a 10% deficit was okay (I was hungry but could mostly ignore it). A 25% deficit was very annoying and about as much as I'd care to do.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by dgabriel on Sunday June 28, 2026 @06:19PM (#48712314)

I did a lot of things, but all of them required a massive amount of sustained effort. I like that I can order the food I want to eat at a restaurant without looking up all the calories before I go. I like that I can just live my life without food thoughts taking up 60% of my brain space at any given time.

For some people, diet and lifestyle changes help control blood pressure. Other people need to take meds for the rest of their lives, anyway. We don't shame them for it.

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