Re:GLP-1 drugs led to weight loss and reversed depression-li...
by catigula on Saturday June 27, 2026 @11:33PM
(#48704066)
I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.
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Re:GLP-1 drugs led to weight loss and reversed depression-li...
by derekja on Saturday June 27, 2026 @11:53PM
(#48704171)
The primary concern is reduced stomach acid leading to nutrient deficiencies, particularly b12. There have been some long term studies correlating to dementia as a result. And some studies that have not found this. So the jury is still out, but keeping an eye on some nutritional markers is not a bad idea.
Re:GLP-1 drugs led to weight loss and reversed depression-li...
by catigula on Sunday June 28, 2026 @04:12PM
(#48711126)
The dementia meta-analyses are a wash. It doesn’t lean strongly either way. I wouldn’t worry about it.
Re:GLP-1 drugs led to weight loss and reversed depression-li...
by dotcoma on Saturday June 27, 2026 @11:48PM
(#48704147)
Good for you, but this mere fact does not mean it’s ideal.
Not a doctor, but I would at least try to look into this. Best of luck!
Re:GLP-1 drugs led to weight loss and reversed depression-li...
by catigula on Sunday June 28, 2026 @04:16PM
(#48711170)
Why do you think I haven’t looked into it?
You’re not providing anything of note, so merely saying “I’ve looked into it. I’m good” seems like it’s the correct reply.
Re:GLP-1 drugs led to weight loss and reversed depression-li...
by mapkkk on Sunday June 28, 2026 @06:15AM
(#48706038)
Definitely not a good idea to be on it longer than 2 months. If we can't treat the underlying condition and the patient needs life-long acid suppression therapy, we switch to H2 receptor antagonists, like cimetidine.
Long term PPI use has non-trivial risks, including magnesium and other micronutrient deficiencies, and can lead to things like SIBO and other primarily gut related morbidity.
I would definitely suggest sitting down with your doctor if you were not specifically instructed to take it for that long.
Re:GLP-1 drugs led to weight loss and reversed depression-li...
by catigula on Sunday June 28, 2026 @04:14PM
(#48711144)
I hate to tell you this, but recommending cimetidine basically makes you a modern day sawbones.
I’d recommended getting up to date knowledge about the options before providing advice on them, starting with safer h2 antagonists like famotidine.